What's Underneath It All?

ALS is a disease with no known cause and no cure. Decade after decade we hear about "promising" science, but so far, the promise hasn't delivered what is needed to stop this terrorist of a disease.

When we hear of optimistic scientific breakthroughs, they are often related to some very specific scenarios -- specific mouse models or specific genes.

The term "the tip of the iceberg" is certainly one that comes to mind whenever we hear of new "promise."

My question for ALS researchers who have found reasons for optimism is this -- Are we looking at the tip of the iceberg, the tips of the iceberg, or the tips of many icebergs?